Genome Anatomy
The goal of cgap is to characterize cancer at a molecular level by providing a platform with readily accessible updated data and a set of tools such that researchers can e. Rather than an outward exploration of the planet or the cosmos the hgp was an inward voyage of discovery led by an international team of researchers looking to sequence and map all of the genes together known as the genome of members of our species homo sapiens.
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Whole genome sequencing gives us the ability to detect certain variants of disease.
Genome anatomy. Detailed knowledge of the anatomy of the human genome is likely to elucidate normal regulatory mechanisms in volved in differentiation and all aspects of genetic function. Mapping information and knowledge of reg ulatory mechanisms will probably be critically impor tant to efforts to replace mutant genes with normal ones. When we speak of mapping genes on chromosomes we use a carto graphicmetaphoranequallyappropri ate anatomic metaphor is the anatomy.
The anatomy of the human genome a neo vesalian basis for medicine in the 21st century victor a. It also provides tools for viewing and analysis of the data allowing for identification of genes involved in various aspects of tumor progression. So when you started as a single cell organism you in fact had two meters of dna.
The mitelman database relates chromosomal aberrations to tumor characteristics based either on individual cases or associations. The cancer genome anatomy project created by the national cancer institute in 1997 and introduced by al gore is an online database on normal pre cancerous and cancerous genomes. The mitelman database of chromosome aberrations and gene fusions in cancer has a new home at the institute for systems biology cancer genomics cloud.
The cancer genome anatomy project cgap data no longer exist. The human genome project hgp was one of the great feats of exploration in history. Ideally with this knowledge people can work with healthcare professionals in order to either prevent a disease altogether or to reduce its impact an idea called personalized medicine.
Genome anatomy is the structure of all the genetic information in the haploid portion of chromosomes of a cell. The anatomy of the prokaryotic genome because of the relatively small sizes of prokaryotic genomes many complete genome sequences for various bacteria and archaea have been published over the last few years. Based on this premise the cancer genome anatomy project was initiated with the broad goal of determining the comprehensive molecular characterization of normal premalignant and malignant tumor cells thus making a reality the identification of all major cellular mechanisms leading to tumor initiation and progression strausberg rl dahl ca and klausner rd.
Mckusick md t he linear arrangement of genes on our chromosomes is part of our microanatomy. This genome is in fact a series of 23 molecules of dna which all together amount to 3 billion base pairs of dna and approximately one meter of that molecule.
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